Could immuno-oncology treatments get a boost from a 64-year-old antipsychotic?

Prochlorperazine (PCZ) s a known inhibitor of endocytosis, the process by which cells ingest materials. An Australian team showed that combining PCZ with Erbitux or Bavencio in mouse models created greater tumor shrinkage than what was seen with either anti-cancer drug on its own. They're now planning to test the combination approach in people with several tumor types.

Could immuno-oncology treatments get a boost from a 64-year-old antipsychotic?
Prochlorperazine (PCZ) s a known inhibitor of endocytosis, the process by which cells ingest materials. An Australian team showed that combining PCZ with Erbitux or Bavencio in mouse models created greater tumor shrinkage than what was seen with either anti-cancer drug on its own. They're now planning to test the combination approach in people with several tumor types.